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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10688

Title: Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities
Authors: Ekuadzi, Edmund
Dickson, Rita
Fleischer, Theophilus
Annan, Kofi
Pistorius, Dominik
Oberer, Lukas
Keywords: Margaritaria discoidea
Flavonoid glycosides
Antibacterial activities
Antioxidant activities
Issue Date: 2014
Publisher: Phytotherapy Research
Citation: Phytotherapy Research, 28: 1855–1860 (2014), DOI: 10.1002/ptr.5212
Abstract: One new flavonoid glycoside, along with three known flavonoid glycosides were isolated from the stem bark of Margaritaria discoidea, which is traditionally used in the management of wounds and skin infections in Ghana. The new flavonoid glycoside was elucidated as hydroxygenkwanin-8-C-[α-rhamnopyranosyl-(1→6)]-β- glucopyranoside (1) on the basis of spectroscopic analysis. The isolated compounds demonstrated free-radical scavenging as well as some level of antibacterial activities. Microorganisms including Staphylococcus aureus are implicated in inhibiting or delaying wound healing. Therefore, any agent capable of reducing or eliminating the microbial load present in a wound as well as decreasing the levels of reactive oxygen species may facilitate the healing process. These findings therefore provide some support to the ethnopharmacological usage of the plant in the management of wounds.
Description: An article published by Phytotherapy Research, 28: 1855–1860 (2014), DOI: 10.1002/ptr.5212
URI: http://hdl.handle.net/123456789/10688
Appears in Collections:College of Health Sciences

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