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|Title: ||Some neurological effects of the ethanolic stem bark extract of Cussonia bancoensis Aubrev and Pellgr (Araliaceae|
|Authors: ||Mensah, A. Y.|
Mireku, E. A.
Mensah, M. L. K.
Amponsah, I. K.
|Issue Date: ||2014|
|Publisher: ||Journal of Pharmacognosy and Phytochemistry|
|Citation: ||Journal of Pharmacognosy and Phytochemistry 2014; 2 (6): 213-218|
|Abstract: ||In this study, some neurological effects of the 70% ethanolic stem bark extract (CB) of Cussonia
bancoensis, Aubrev and Pellgr, (Araliaceae) were investigated in mice using various models. The
effect of CB on the central nervous system (CNS) was studied using changes in general behavioural
profiles (Irwin’s test), tail flick test, potentiation of pentobarbitone induced sleep and effect on
convulsion threshold in mice. Administration of doses between 100 and 3000 mg/kg body weight
showed marked reduction in spontaneous activity, decreased response to touch and pain, moderate
loss of balance, presence of ptosis and sedation. There was no mortality recorded after 24 and 48 h of
administration of a maximum dose of 3000 mg/kg body weight. The study has shown that the stem
bark extract at doses between 300 and 3000 mg/kg body weight has a dose -dependent sedative
effect. This was observed as a reduction of locomotor activity and marked potentiation of
pentobarbitone induced sleep onset and duration in mice. The ethanolic extract of C. bancoensis (CB)
also significantly increased latency to tail withdrawal at 54 ±1 ºC in a dose dependent manner. Effect
of CB extract on the onset and duration of pentylenetetrazole (PTZ) induced seizures was however
insignificant. Based on these results, the traditional use of C. bancoensis in the management of pain
and its ability to induce dizziness and sedation are justified. This observation may be attributed to the
presence of plant secondary metabolites such as saponins and tripterpenoids which tested positive in
the preliminary phytochemical screening of the powdered stem bark.|
|Description: ||An article published by Journal of Pharmacognosy and Phytochemistry 2014; 2 (6): 213-218|
|Appears in Collections:||College of Health Sciences|
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