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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10694

Title: Anti-inflammatory and anti-oxidant activities of Secamone afzelii (Rhoem) Ascleipiadaceae
Authors: Mensah, A. Y.
Mireku, E. A.
Okwuonu, V.
Keywords: Secamone afzelii, carrageenan
Antioxidant
Antiinflammatory
Issue Date: 2014
Publisher: Journal of Medical and Biomedical Sciences
Citation: Journal of Medical and Biomedical Sciences (2014) 3(1): 23-30
Abstract: Secamone afzelii is used traditionally in Ghana mainly as a wound healing agent. This study re-ports the anti-inflammatory and antioxidant properties of S. afzelii. The anti-inflammatory activity was determined by the carrageenan-induced paw oedema method in 7 day old chicks and antioxi-dant property by the 2,2–diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, total antioxi-dant and total phenol content determinations. In doses of 30, 100 and 300 mg kg-1, the methanol extract of the leaves reduced carrageenan-induced oedema by 24.70%, 33.41% and 44.26% respec-tively. The leaf extract exhibited free radical scavenging activity with an IC50 of 16.73 μg mL-1 com-pared to ascorbic acid which gave an IC50 of 2.01 μg mL-1. In the total phenol content determina-tion, the leaf extract was found to contain 56.86 mg g-1 calculated as tannic acid equivalent of the dry weight of extract. The extract also demonstrated remarkable antioxidant effect in the total anti-oxidant capacity determinations and had an 87% correlation with the amount of phenolic content present.
Description: n article published by Journal of Medical and Biomedical Sciences (2014) 3(1): 23-30, doi: http://dx.doi.org/10.4314/jmbs.v3i1.4
URI: http://hdl.handle.net/123456789/10694
Appears in Collections:College of Health Sciences

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