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|Title: ||Antiinflammatory Properties of the Stem-bark of Anopyxis klaineana and its Major Constituent, Methyl Angolensate|
|Authors: ||Mireku, Evelyn A.|
Mensah, Abraham Y.
Mensah, Merlin L. K.
Tocher, Derek K.
|Keywords: ||Anopyxis klaineana|
|Issue Date: ||2014|
|Publisher: ||Phytotherapy Research|
|Citation: ||Phytotherapy Research, 28: 1855–1860 (2014), DOI: 10.1002/ptr.5212|
|Abstract: ||Anopyxis klaineana (Pierre) Engl. (Rhizophoraceae) is one of the reputedWest African folkloric medicines that
has never been investigated for its pharmacological effects or phytochemical constituents. In the present study,
the antiinflammatory properties of the stem-bark extracts were evaluated using the carrageenan-induced paw
oedema model in chicks. The petroleum ether, ethyl acetate and methanol extracts all showed a time and
dose-dependent antiinflammatory effect over the 5-h observation period. Phytochemical analysis of the most active
extract (methanol extract) yielded the principal constituent that was identified as methyl angolensate through
extensive spectroscopic and X-ray analysis studies. Although slightly less potent (ED50, 4.05± 0.0034mg/kg, orally)
than the positive control, diclofenac (ED50, 2.49 ± 0.023, intraperitoneally n = 5), this first ever compound isolated
from A. klaineana showed promising antiinflammatory activity that may account to some of the reported medicinal
uses of the plant.|
|Description: ||An article published by Phytotherapy Research, 28: 1855–1860 (2014), DOI: 10.1002/ptr.5212|
|Appears in Collections:||College of Health Sciences|
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