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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10696

Title: Anti-inflammatory and antioxidant activities of Commelina diffusa (Commelinaceae)
Authors: Mensah, Abraham Yeboah
Mireku, Evelyn Afua
Oppong-Damoah, Aboagyewaa
Amponsah, Isaac Kingsley
Keywords: Commelina diffusa
Anti-inflammatory
Total phenol
Total antioxidant capacity
Reactive oxygen species
Issue Date: 2014
Publisher: World Journal of Pharmaceutical Sciences
Citation: World Journal of Pharmaceutical Sciences, 2014; 2(10): 1159-1165
Abstract: The leaves of Commelina diffusa are used traditionally for the treatment of a variety of disease conditions in Ghana, including inflammation and wound healing. In this study, the ethanolic extract of the leaves of Commelina diffusa was investigated for its anti-inflammatory and antioxidant properties. Carrageenan induced foot oedema in 7-day old chicks was used to investigate the anti-inflammatory properties of the extract while DPPH radical scavenging test, total phenolic content and total antioxidant capacity assays were used to investigate the antioxidant property of the extract. Commelina diffusa ethanolic leaf extract significantly (P<0.05) reduced the total foot oedema in a dose dependent manner. The maximum percentage inhibition of inflammation given by the extract was 43.55% (300 mg kg-1). The extract also showed potent DPPH scavenging effect with an IC50 of 11.35 μg/ml. Total phenolic content was found to be 193.7 mg/g of extract calculated as tannic acid equivalent. Total antioxidant capacity of the extract was found to be 130.5 mg/g of (ascorbic acid equivalent). Thus, the study justifies the traditional use of the leaves of Commelina diffusa in the treatment of various inflammatory conditions.
Description: An article published by World Journal of Pharmaceutical Sciences, 2014; 2(10): 1159-1165
URI: http://hdl.handle.net/123456789/10696
Appears in Collections:College of Health Sciences

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