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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10704

Title: Anti-uveitogenic effect of Xylopic acid in Sprague-Dawley rats
Authors: Kyei, Samuel
Ameyaw, Elvis Ofori
Koffuor, George Asumeng
Boampong, Johnson Nyarko
Woode, Eric
Abueh, Blessing Barilee
Osei, Owusu-Afriyie
Karikari, Akua Afriyie
Keywords: Uveitis
Xylopic acid
Xylopia aethiopica
Issue Date: 2014
Publisher: European Journal of Experimental Biology
Citation: European Journal of Experimental Biology, 2014, 4(6):32-39
Abstract: Uveitis, intraocular inflammatory disorder is one of the leading causes of blindness in the world. This study investigated the curative effect of xylopic acid on endotoxin-induced uveitis in Sprague-Dawley rats. Uveitis was induced in rats by injecting 110 μg lipopolysaccharide (LPS) subcutaneously. Clinical signs of uveitis were assessed with a slit lamp. Polymorphonuclear neutrophils and total proteins in the aqueous humour of the eyes were estimated and these markers of inflammation were elevated in the control groups. Histopathological assessments of inflammation in the ocular tissues were also performed. There were significant reductions (P≤ 0.05) in vasodilatation of iris vessels, exudation, polymorphonuclear neutrophils and total proteins in the aqueous humour of xylopic acid and prednisolone treated uveitic rats compare to the untreated (control). Histopathological assessments revealed resolution of uveitis in treatment groups but not the untreated. This shows that oral administration of xylopic acid has ocular anti-inflammatory effect in Sprague-Dawley rats.
Description: An article published by European Journal of Experimental Biology, 2014, 4(6):32-39
URI: http://hdl.handle.net/123456789/10704
Appears in Collections:College of Health Sciences

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