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|Title: ||Physician and patient preferences for sustained release antihypertensive preparations in the Kumasi Metropolis, Ghana|
|Authors: ||Kipo, Samuel L.|
Buabeng, Kwame O.
Anto, Berko P.
|Keywords: ||Sustained release|
|Issue Date: ||2015|
|Publisher: ||West African Journal of Pharmacy|
|Citation: ||West African Journal of Pharmacy (2015) 26 (1)|
|Abstract: ||Background: Non-adherence to therapy is a major reason for the low control rate of hypertension in Ghana
today. Sustained release (SR) antihypertensive preparations are useful in promoting adherence to therapy
because of the reduced daily dosing frequency, stable drug levels and reduced toxicity which enhances
compliance. One major concern about SR antihypertensives is whether they can be substituted with one
another to produce the same effect.
Objectives: This study sought to determine the preferences of physicians and patients for various SR
antihypertensive medications in the Kumasi metropolis of Ghana. The views of the respondents on whether
the brands of the most used SR antihypertensive were therapeutically equivalent and interchangeable were
Methods: Seventy-three (73) community pharmacies, 66 doctors and 150 patients in 50 public, private and
mission hospitals and clinics within the Kumasi metropolis were purposively sampled. Respondents were
interviewed via interviewer administered structured questionnaires and the information gathered was coded,
entered into SPSS software version (16) and analysed. The results were presented as frequencies and
proportions, and in tables as well as in figures.
Results: SR nifedipine was the most stocked and used SR antihypertensive drug while Nifecard XL (30 mg) was
the preferred brand of patients and doctors. Clinicians considered effectiveness and compliance as two major
reasons for their preference for SR nifedipine while patients considered affordability and availability. Sixty
percent of prescribers and 41% of patients were of the opinion that all brands of SR nifedipine were
Conclusion: There is a gap between prescribers and patients about SR nifedipine brands interchangeability
which needs to be bridged to optimize their use to attain better treatment outcomes in Ghana. There is need
for continuous education on concepts of therapeutic equivalence and generics substitution for all
stakeholders to address the problem of non-adherence to hypertension therapy in Ghana.|
|Description: ||An article published by West African Journal of Pharmacy (2015) 26 (1)|
|Appears in Collections:||College of Health Sciences|
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