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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10949

Title: Evaluation of the hepatoprotective potential of hydroethanolic extract of Ficus pumila l. on CCl4 induced liver damage in rats
Authors: Osei, Asibey
Larbie, Christopher
Torkornoo, Dennis
Nyanor, Emmanuel
Keywords: Silymarin
liver damage
Hepatoprotective
Ficus pumila,
carbon tetrachloride
Issue Date: Jul-2016
Publisher: GJRMI
Citation: Global J Res. Med. Plants & Indigen. Med. | Volume 5, Issue 7 | July 2016 | 217–225
Abstract: Liver diseases and defects are on the constant rise all around the world, with the available pharmaceutical drugs not being efficient for treatment and also presenting adverse effects after use. The general objective of the study was to determine the hepatoprotective effect of 50% hydroethanolic extract of Ficus pumila on carbon tetrachloride (CCl4) induced liver damage in rats. In this work, liver damage was induced in experimental animals by administering 1 ml/kg CCl4 orally, after which the rats were treated with 50% hydro-ethanolic extract of F. pumila and Silymarin, a standard hepatoprotective drug. 50% hydroethanolic extract at 100 and 250 mg/kg were administered for 7 days by oral route. Hepatoprotective effect was studied by assaying the activity of hepatobiliary enzymes such as ALT, AST, ALP, GGT and biochemical parameters such as cholesterol, triglycerides, high density lipoproteins, total bilirubin, direct bilirubin concentration and indirect bilirubin concentration. Body weight and liver weights (absolute and relative) of the rats were also measured. The activity of all the hepatobiliary enzymes registered significant increases upon CCl4 administration. There were also increases in cholesterol and triglyceride concentration and in total and indirect bilirubin, an indication of liver damage. F. pumila at all doses significantly (0.05– 0.001) restored liver function compared to the Silymarin control and also increased body and absolute liver weight. The results therefore indicate that leaves of F. Pumila possess hepatoprotective activity.
Description: This article was published in Global J Res. Med. Plants & Indigen. Med. | Volume 5, Issue 7 | July 2016 | 217–225
URI: http://hdl.handle.net/123456789/10949
Appears in Collections:College of Science

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