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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10950

Title: Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana
Authors: Brown, Charles
Amuzu, Dominic Selorm Yao
Larbie, Christopher
Keywords: chloroquine;
malaria
CYP2C8 mutation
drug toxicity
artesunate amodiaquine
Issue Date: 2016
Publisher: International Journal of Biochemistry Research & Review
Citation: International Journal of Biochemistry Research & Review 12(3): 1-9, 2016, Article no.IJBCRR.25680
Abstract: Aim: The study determined prevalence of clinically relevant CYP2C8*5 polymorphism in 80 unrelated individuals, from selected ethnic groups in Southern Ghana. Medical history on adverse drug reactions of the subjects and level of dependency on drugs metabolized by CYP2C8 enzyme was obtained by questionnaire. Allele Specific-PCR analyses were used to genotype CYP2C8*5 alleles in the study subjects. Results: Allelic frequency for CYP2C8*5 was 83.75% which was statistically significant (p<0.05). There was no significant difference (p> 0.05) in the prevalence of CYP2C8*5 allele within the ethnic groups. Also, there was no significant association (p >0.05) between CYP2C8*5 allele and reported ADRs. Many (88.75%) of the study subjects depended highly (>1-3x in a year) on drugs metabolized by CYP2C8. Conclusions: The high prevalence of CYP2C8*5 determined in the study population may indicate a high risk of toxicity in using drugs metabolize by CYP2C8 since CYP2C8*5 mutants have been reported to have a reduced enzymatic activity. This is the first reported study on prevalence of CYP2C8*5 in Ghanaians.
Description: This article was published in the International Journal of Biochemistry Research & Review 12(3): 1-9, 2016, Article no.IJBCRR.25680
URI: http://hdl.handle.net/123456789/10950
ISSN: 2231-086X
Appears in Collections:College of Science

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