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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10964

Title: Bilirubin lowering potential of Annona muricata (linn.) in temporary jaundiced rats
Authors: Arthur, Fareed K.N.
Woode, Eric
Terlabi, Ebenezer O.
Larbie, Christopher
Keywords: Phenylhydrazine
Annona muricata
bilirubin
jaundice
rats
Issue Date: 2012
Publisher: American Journal of Pharmacology and Toxicology
Citation: American Journal of Pharmacology and Toxicology 7 (2): 33-40, 2012
Abstract: Problem statement: Annona muricata is used in Ghanaian traditional medicine for the treatment of jaundice. Work done has demonstrated A. muricata to be effective in treating carbon tetrachloride-and acetaminophen-induced hepatic damage, hepatic jaundice and toxicologically safe up to 1000 mg kg1 in animals. Current study evaluated the bilirubin-lowering potential of A. muricata aqueous extract in phenylhydrazine-(40 mg kg1) induced jaundice in adult rats. Approach: Jaundice was assessed by measuring the levels of total bilirubin and direct bilirubin in phenylhydrazine-treated animals with or without drug treatment with curative, prophylactic study and in animals with reduced liver capacity. Results: Phenylhydrazine induced jaundice in animals from 1.50 µmol L1±0.00 total bilirubin in normal animals up to 29.25 µmol L1±2.21 in animals with reduced liver capacity. The hyperbilirubinaemia were restored close to normal levels in animals treated with A. muricata aqueous extract at 50 and 400 mg kg1. Total bilirubin level was reduced to 6.22 µmol L1± 0.27 at 50 mg, 5.68 µmol L1±0.36 at 400 mg kg 1 and 7.94 µmol L1±0.79 with Silymarin, significantly lower (p<0.001) compared with the vehicle group (16.90 µmol L1±2.21) maintained with distilled water. Conclusion: Therefore, A. muricata aqueous extract can be used to reduce bilirubin concentration in jaundiced subjects.
Description: This article was published in the American Journal of Pharmacology and Toxicology 7 (2): 33-40, 2012
URI: http://hdl.handle.net/123456789/10964
ISSN: 1557-4962
Appears in Collections:College of Science

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