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|Title: ||Bilirubin lowering potential of Annona muricata (linn.) in temporary jaundiced rats|
|Authors: ||Arthur, Fareed K.N.|
Terlabi, Ebenezer O.
|Issue Date: ||2012|
|Publisher: ||American Journal of Pharmacology and Toxicology|
|Citation: ||American Journal of Pharmacology and Toxicology 7 (2): 33-40, 2012|
|Abstract: ||Problem statement: Annona muricata is used in Ghanaian traditional medicine for the treatment of jaundice. Work done has demonstrated A. muricata to be effective in treating carbon tetrachloride-and acetaminophen-induced hepatic damage, hepatic jaundice and toxicologically safe up to 1000 mg kg1 in animals. Current study evaluated the bilirubin-lowering potential of A. muricata aqueous extract in phenylhydrazine-(40 mg kg1) induced jaundice in adult rats. Approach: Jaundice was assessed by measuring the levels of total bilirubin and direct bilirubin in phenylhydrazine-treated animals with or without drug treatment with curative, prophylactic study and in animals with reduced liver capacity. Results: Phenylhydrazine induced jaundice in animals from 1.50 µmol L1±0.00 total bilirubin in normal animals up to 29.25 µmol L1±2.21 in animals with reduced liver capacity. The hyperbilirubinaemia were restored close to normal levels in animals treated with A. muricata aqueous extract at 50 and 400 mg kg1. Total bilirubin level was reduced to 6.22 µmol L1± 0.27 at 50 mg, 5.68 µmol L1±0.36 at 400 mg kg 1 and 7.94 µmol L1±0.79 with Silymarin, significantly lower (p<0.001) compared with the vehicle group (16.90 µmol L1±2.21) maintained with distilled water. Conclusion: Therefore, A. muricata aqueous extract can be used to reduce bilirubin concentration in jaundiced subjects.|
|Description: ||This article was published in the American Journal of Pharmacology and Toxicology 7 (2): 33-40, 2012|
|Appears in Collections:||College of Science|
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