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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10968

Title: Evaluation of hepatoprotective effect of aqueous extract of Annona muricata(Linn.) leaf against carbon tetrachloride and acetaminophen-induced liver damage
Authors: Arthur, Fareed K. N.
Larbie, Christopher
Woode, Eric
Terlabi, Ebenezer O.
Keywords: acetaminophen
jaundice
Annona muricata
carbon tetrachloride
Issue Date: 2012
Publisher: Journal of Natural Pharmaceuticals
Citation: Journal of Natural Pharmaceuticals, Volume 3, Issue 1, January-June, 2012
Abstract: Introduction:Liver diseases and jaundice have continued to be a major health problem in the world’s population with most conventional drugs not being adequate for treatment. The study was designed to evaluate the hepatoprotective activity and antijaundice property of aqueous extract of Annona muricata (Linn.) against carbon tetrachloride- (CCl 4 ) and acetaminophen-induced hepatotoxicity in Sprague–Dawley rat model. Materials and Methods:Liver damage and hepatic jaundice were induced in experimental animals by administering CCl 4 and acetaminophen after pretreatment with aqueous extract of A. muricata. The aqueous extract at 50, 100, 200, and 400 mg/kg was administered for 7 days by oral route. Silymarin (100 mg/kg) was given as the standard hepatoprotective drug. Hepatoprotective effect was studied by assaying the activity of serum marker enzymes such as alanine aminotransferase, alkaline phosphatase, cholesterol, and triglycerides while antijaundice effect was assayed by measuring serum total bilirubin and indirect bilirubin concentration. Results:The activity of all the marker enzymes registered significant increases in CCl 4 - and acetaminophen-treated rats, decreases in cholesterol and triglyceride concentration, and increases in total and indirect bilirubin, an indication of hepatic jaundice. A. muricataat all doses significantly restored liver function toward normal levels which compared well against silymarin control. Histopathological analysis of liver sections confirmed biochemical investigations. Conclusion:The results indicate that leaves of A. muricatapossess hepatoprotective activity and can treat hepatic jaundice.
Description: This article was published in the Journal of Natural Pharmaceuticals, Volume 3, Issue 1, January-June, 2012
URI: http://hdl.handle.net/123456789/10968
ISSN: 2229-5119
Appears in Collections:College of Science

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