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|Title: ||Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula|
|Authors: ||Annan, Kofi|
Gyan, Ben A.
Lukas Oberer, Lukas Oberer
|Keywords: ||Bisclerodane imide|
|Issue Date: ||2015|
|Citation: ||K. Annan et al. / Phytochemistry Letters 11 (2015) 28–31|
|Abstract: ||Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified
from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene,
pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,
16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the
WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects.
They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 mM.|
|Description: ||This article was published in K. Annan et al. / Phytochemistry Letters 11 (2015) 28–31|
|Appears in Collections:||College of Health Sciences|
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