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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10974

Title: Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula
Authors: Annan, Kofi
Ofori, Michael
Ekuadzi, Edmund
Asare, Cindy
Sarpong, Kwame
Gyan, Ben A.
Pistorius, Dominik
Lukas Oberer, Lukas Oberer
Keywords: Bisclerodane imide
Clerodane
Diterpenes
Antiplasmodial
Polyalthia longifolia
Issue Date: 2015
Publisher: Elsevier
Citation: K. Annan et al. / Phytochemistry Letters 11 (2015) 28–31
Abstract: Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15, 16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 mM.
Description: This article was published in K. Annan et al. / Phytochemistry Letters 11 (2015) 28–31
URI: http://hdl.handle.net/123456789/10974
Appears in Collections:College of Health Sciences

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