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|Title: ||Antimicrobial and modulation effects of selected Ghanaian medicinal plants|
|Authors: ||Ekuadzi, E.|
Fianu, M. G.
Dickson, R. A.
Fleischer, T. C.
Dapaah, S. O.
Reynolds, E. O.
Akpabey, E. S.
|Keywords: ||Commelina nudiflora|
|Issue Date: ||2016|
|Citation: ||Journal of Science and Technology, Vol. 36, No. 3 (2016), pp 1-7|
|Abstract: ||The alarming rise in the incidences of multidrug-resistant microorganisms and the decline in
new antibiotic discovery make the search for new antimicrobial agents or efforts at restoring the
activity of older antibiotics to which the microbeshave developed resistance very necessary. The
aim of the present study is to investigate the antimicrobial and modulation effects of the 70%
ethanol extracts of Lannea schimperi, Commelina nudiflora and Piliostigma reticulatum against
susceptible strains of microorganisms. Using the broth microdilution method, the minimum inhibitory concentrations (MICs) of the extracts were determined. The checkerboard assay was
used to determine the modulation effects when sub-inhibitory concentrations of plant extracts
were combined with the standard antibiotics. All three plants extracts possessed weak antimicrobial effects. For the modulation experiments, fifteen of the twenty-seven combinatorial cases
yielded biologically significant effects. The ethanol extracts of the three plants studied here are
good modulators as they reduced the MIC of ciprofloxacin and ketoconazole by factors that are
comparable to that of reserpine. However the exact compounds and their exact mechanism of
modulation require further investigation.|
|Description: ||This article was published in the Journal of Science and Technology, Vol. 36, No. 3 (2016), pp 1-7|
|Appears in Collections:||College of Health Sciences|
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