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|Title: ||Effects of Antioxidant Micronutrients against CVD Risk in Type 2 Diabetes Mellitus: A Systematic Review|
|Authors: ||Asamoah-Boakye, Odeafo|
|Keywords: ||Cardiovascular diseases (CVDs)|
Type 2 diabetes mellitus
|Issue Date: ||2017|
|Publisher: ||Journal of Nutritional Disorders & Therapy|
|Citation: ||Journal of Nutritional Disorders & Therapy, 2017, 7:2 DOI: 10.4172/2161-0509.1000214|
|Abstract: ||Diabetes mellitus is associated with hyperglycemia, which promotes oxidative stress through production of free
radicals which may lead to diabetic complications such as cardiovascular diseases. However,it is proposed that
dietary intakes of antioxidant micronutrients may help reduce oxidative stress in diabetes mellitus. The objective was
to evaluate the protective effects of antioxidant micronutrients against CVD risk among type 2 diabetics.
Method: A systematic literature review including detailed search strategy was developed to search PubMed,
PMC, PLOSONE, Google scholar and cochrane. Research articles were retrieved, screened and relevant articles
were extracted. The exposure for review were zinc, vitamin E, and selenium, whereas measured outcomes were
effects of antioxidant micronutrients on type 2 diabetes: reduced FBG and HbA1c, reduced lipidemia, improved
antioxidant status, reduced oxidative stress.
Results: Among six cross-sectional studies; five studies indicated serum zinc were significantly reduced in type
2 diabetics than controls, whereas one study showed a higher serum selenium in type 2 diabetics than controls.
Among five case-control studies used, two studies found serum zinc was lowered among type 2 diabetics than
controls. Another study found serum vitamin E was reduced in type 2 diabetics than controls (p<0.05). The other
studies showed supplementation of vitamin C, E improved significantly in levels of fasting blood glucose and glycated
hemoglobin (p<0.05, p<0.001 respectively). However, a case control study between type 2 diabetics with glycated
haemoglobin <7% and ≥ 7% showed no difference in serum zinc levels (p=0.168). Out of five randomized controlled
trials, two studies showed significant difference in fasting blood glucose, total antioxidant capacity, malondialdehyde
in type 2 diabetics who received supplemented enriched tocotrienol canola oil at the end of study. However, type 2
diabetics supplemented with omega-3 plus vitamin E, and zinc plus vitamin C showed no significant differences in
cardiovascular risk markers compared to controls. Also, two studies which either supplemented type 2 diabetics with
fermented diet containing supplemented chromium and zinc found no significant differences in glycated hemoglobin
compared to placebo groups.
Conclusion: Antioxidant micronutrients could significantly reduce risk of cardiovascular diseases in type 2
diabetes and hence require further studies to ascertain its effects.|
|Description: ||An article published by Journal of Nutritional Disorders & Therapy, 2017, 7:2 DOI: 10.4172/2161-0509.1000214|
|Appears in Collections:||College of Science|
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