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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11239

Title: Antimicrobial Activities and Time-Kill Kinetics of Extracts of Selected Ghanaian Mushrooms
Authors: Appiah, Theresa
Boakye, Yaw Duah
Agyare, Christian
Issue Date: 2017
Publisher: Evidence-Based Complementary and Alternative Medicine
Citation: Evidence-Based Complementary and Alternative Medicine, Volume 2017, Article ID 4534350, 15 pages; https://doi.org/10.1155/2017/4534350
Abstract: The rapid rise of antimicrobial resistance is a worldwide problem. This has necessitated the need to search for new antimicrobial agents. Mushrooms are rich sources of potential antimicrobial agents. This study investigated the antimicrobial properties of methanol extracts of Trametes gibbosa, Trametes elegans, Schizophyllum commune, and Volvariella volvacea. Agar well diffusion, broth microdilution, and time-kill kinetic assays were used to determine the antimicrobial activity of the extracts against selected test organisms. Preliminary mycochemical screening revealed the presence of tannins, flavonoids, triterpenoids, anthraquinones, and alkaloids in the extracts.Methanol extracts of T. gibbosa, T. elegans, S. commune, and V. volvacea showed mean zone of growth inhibition of 10.00 ± 0.0 to 21.50 ± 0.84, 10.00 ± 0.0 to 22.00 ± 1.10, 9.00 ± 0.63 to 21.83 ± 1.17, and 12.00 ± 0.0 to 21.17 ± 1.00 mm, respectively. The minimum inhibitory concentration of methanol extracts of T. gibbosa, T. elegans, S. commune, and V. volvacea ranged from4.0 to 20, 6.0 to 30.0, 8.0 to 10.0, and 6.0 to 20.0mg/mL, respectively. Time-kill kinetics studies showed that the extracts possess bacteriostatic action.Methanol extracts of T. gibbosa, T. elegans, S. commune, andV. volvacea exhibited antimicrobial activity and may contain bioactive compounds which may serve as potential antibacterial and antifungal agents.
Description: An article published by Evidence-Based Complementary and Alternative Medicine, Volume 2017, Article ID 4534350, 15 pages; https://doi.org/10.1155/2017/4534350
URI: http://hdl.handle.net/123456789/11239
Appears in Collections:College of Health Sciences

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