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|Title: ||Antimicrobial and anti-inflammatory properties of Funtumia elastica|
|Authors: ||Agyare, Christian|
Koffuor, George Asumeng
Boakye, Yaw Duah
Mensah, Kwesi Boadu
|Issue Date: ||2013|
|Publisher: ||Pharmaceutical Biology|
|Citation: ||Christian Agyare, George Asumeng Koffuor, Yaw Duah Boakye & Kwesi Boadu Mensah (2013) Antimicrobial and anti-inflammatory properties of Funtumia elastica, Pharmaceutical Biology, 51:4, 418-425, DOI: 10.3109/13880209.2012.738330|
|Abstract: ||Context: Funtumia elastica (Preuss) Stapf. (Apocynaceae) has a long ethnopharmacological history for uses such as
treatment of whooping cough, asthma, blennorhea, painful menstruation, fungal infections, and wounds.
Objective: To investigate the antimicrobial and anti-inflammatory properties of ethanol extracts from the leaves
and stem bark of Funtumia elastica based on its ethnopharmacological uses and also determine the secondary
metabolites present in the extracts.
Materials and methods: The antimicrobial activities of ethanol leaf and bark extracts of F. elastica were determined
using the microdilution technique (MIC determination) and agar diffusion method using 10, 25, and 50 mg/mL
concentrations against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida
albicans, Aspergillus flavus and Aspergillus niger as test organisms. Anti-inflammatory activities of the doses of extracts
at 30, 100, and 300 mg/kg per body weight were determined by carrageenan-induced edema in the footpad of 7-dayold
chicks and the foot volumes measured at hourly interval post-treatment for 5 h.
Results: The MIC ranges of both ethanol leaf and bark extracts against the test organisms were 125 (lowest MIC)
to1550 μg/mL (highest MIC) and 125 (lowest MIC) to 1750 μg/mL (highest MIC), respectively. The ethanol leaf and bark
extract of F. elastica showed significant anti-inflammatory activity (p ≤ 0.001) at 30, 100 and 300 mg/kg. Preliminary
phytochemical screening revealed that F. elastica bark contains hydrolysable tannins, sapogenetic glycosides, steroids
and saponins while the leaves contain hydrolysable tannins, flavonoids, starch and alkaloids. Tannin contents of the
leaf and stem bark were 2.4 and 1.3% w/w (related to the dried material), respectively.
Discussion and conclusion: Both ethanol leaf and bark extracts of F. elastica showed antimicrobial and anti-inflammatory
activities and these pharmacological properties may be responsible for the ethnomedicinal uses of the leaves and
stem bark of the plant.|
|Description: ||An article published by Christian Agyare, George Asumeng Koffuor, Yaw Duah Boakye & Kwesi
Boadu Mensah (2013) Antimicrobial and anti-inflammatory properties of Funtumia elastica,
Pharmaceutical Biology, 51:4, 418-425, DOI: 10.3109/13880209.2012.738330|
|Appears in Collections:||College of Health Sciences|
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