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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11248

Title: In vitro activity of Cameroonian and Ghanaian medicinal plants on parasitic (Onchocerca ochengi) and free-living (Caenorhabditis elegans) nematodes
Authors: Ndjonka, D.
Agyare, Christian
Luersen, K.
Djafsia, B.
Achukwi, D.
Nukenine, E.N.
Hensel, A.
Liebau, E.
Issue Date: Sep-2011
Publisher: Journal of Helminthology
Citation: Journal of Helminthology, page 1 of 9; doi:10.1017/S0022149X10000635
Abstract: Ethanolic and aqueous extracts of selected medicinal plants from Cameroon and Ghana were assessed for their in vitro anthelmintic activity by using the bovine filarial parasite Onchocerca ochengi and the free living nematode Caenorhabditis elegans, a model organism for research on nematode parasites. Worms were incubated in the presence of different concentrations of extracts and inhibitory effects were monitored at different time points. Among the extracts used in this study, ethanolic extracts of Anogeissus leiocarpus, Khaya senegalensis, Euphorbia hirta and aqueous extracts from Annona senegalensis and Parquetina nigrescens affected the growth and survival of C. elegans and O. ochengi significantly. The mortality was concentration dependent with an LC50 ranging between 0.38 and 4.00mg/ml for C. elegans (after 72 h) and between 0.08 and 0.55mg/ml for O. ochengi after a 24 h incubation time. Preliminary phytochemical screenings on these extracts revealed the presence of flavonoids, alkaloids, saponins, carbohydrates and tannins in the extracts. Accordingly, application of A. leiocarpus, K. senegalensis, E. hirta and A. senegalensis extracts could provide alternatives in the control of helminthic infections.
Description: An article published by Journal of Helminthology, page 1 of 9; September-2011, doi:10.1017/S0022149X10000635
URI: http://hdl.handle.net/123456789/11248
Appears in Collections:College of Health Sciences

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