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|Title: ||In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum|
|Authors: ||Ndjonka, Dieudonné|
Zimbres, Flávia M.
|Issue Date: ||2012|
|Publisher: ||Parasitol Res|
|Citation: ||Parasitol Res (2012) 111:827–834; DOI 10.1007/s00436-012-2905-y|
|Abstract: ||The aim of the study was to screen 11 selected
traditional medicinal plants from West Africa for their in
vitro antiplasmodial activity in order to determine the activity
of single and of combination of plant extracts and to examine
the activity of isolated pure compounds. Ethanolic and aqueous
extracts of the 11 selected plants and pure compounds
from Phyllanthus muellerianus and Anogeissus leiocarpus
were tested in vitro against Plasmodium falciparum 3D7.
Proliferation inhibitory effects were monitored after 48 h.
Among the plants and pure compounds investigated in this
study, geraniin from P. muellerianus, ellagic, gentisic, and
gallic acids from A. leiocarpus, and extracts from A. leiocarpus,
P. muellerianus and combination of A. leiocarpus with P.
muellerianus affected the proliferation of P. falciparum most
potently. Significant inhibitory activity was observed in combination
of A. leiocarpus with P. muellerianus (IC50010.8 μg/ml),
in combination of A. leiocarpus with Khaya senegalensis
(IC50012.5 μg/ml), ellagic acid (IC5002.88 μM), and geraniin
(IC50011.74 μM). In general growth inhibition was
concentration-dependent revealing IC50 values ranging between
10.8 and –40.1 μg/ml and 2.88 and 11.74 μM for plant
extracts and pure substances respectively. Comparison with
literature sources of in vivo and in vitro toxicity data revealed
that thresholds are up to two times higher than the determined
IC50 values. Thus, the present study suggests that geraniin
from P. muellerianus; ellagic acid, gallic acid, and gentisic
acid from A. leiocarpus; and combination of extracts from A.
leiocarpus with either P. muellerianus or K. senegalensis
could be a potential option for malaria treatment.|
|Description: ||An article published by Parasitol Res (2012), 111:827–834; DOI 10.1007/s00436-012-2905-y|
|Appears in Collections:||College of Health Sciences|
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