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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11251

Title: Phytochemical characterization and in vitro wound healing activity of leaf extracts from Combretum mucronatum Schum. &Thonn.: Oligomeric procyanidins as strong inductors of cellular differentiation
Authors: Kisseih, E.
Lechtenberg, M.
Petereit, F.
Sendker, J.
Brandt, S.
Agyare, Christian
Hensel, A.
Issue Date: Mar-2015
Publisher: Journal of Ethnopharmacology
Citation: Journal of Ethnopharmacology, 2015
Abstract: Ethnopharmacological relevance: Leaves from Combretum mucronatum Schum. &Thonn. are traditionally used or wound healing in Western Africa. Aqueous and hydro alcoholic extracts of the dried leaves recently have been shown to stimulate viability of human keratinocytes and dermal fibroblasts. Aim of the study: Phytochemical characterization of the herbal material,development of a validated HPLC methodology for quality control,and pin pointing the under lying pharmacological mechanism under in vitro conditions to understand the impact of C. mucronatum extracts on human skin cells. Materials and methods: Extracts obtained from the leaves from C. mucronatum by using solvents with different polarities(petrol ether,dichloromethane,ethanol–water5 0%,water)were investigated concerning phytochemical composition by GC–MS, LC–MS and in part after fraction at ion and isolation of purified compounds.For quality control of the herbal material an ICH-2 validated UHPLC method was developed for quantification of the lead ...................
Description: An article published by Journal of Ethnopharmacology, 2015
URI: http://hdl.handle.net/123456789/11251
Appears in Collections:College of Health Sciences

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