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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11305

Title: Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni
Authors: Kyere-Davies, Gertrude
Agyare, Christian
Boakye, Yaw Duah
Suzuki, Brian M.
Caffrey, Conor R.
Issue Date: 2018
Publisher: Hindawi
Citation: Journal of Parasitology Research, Volume 2018, Article ID 9431467, 7 pages
Abstract: Schistosomiasis is a disease caused by a flatworm parasite that infects people in tropical and subtropical regions of Sub-Saharan Africa, South America, China, and Southeast Asia. The reliance on just one drug for current treatment emphasizes the need for new chemotherapeutic strategies. The aimof this study was to determine the phenotypic effects of extracts and fractions of leaf and stem bark of Erythrophleum ivorense (family Euphorbiaceae), a tree that grows in tropical parts of Africa, on two developmental stages of Schistosoma mansoni, namely, postinfective larvae (schistosomula or somules) and adults. Methanol leaf and stem bark extracts of E. ivorense were successively fractionated with acetone, petroleum ether, ethyl acetate, and methanol. These fractions were then incubatedwith somules at 0.3125 to 100 𝜇g/mL and with adults at 1.25 𝜇g/mL. The acetone fractions of both themethanol leaf and bark of E. ivorense were most active against the somules whereas the petroleum ether fractions showed least activity. For adult parasites, the acetone fraction of methanol bark extract also elicited phenotypic changes. The data arising provide the first step in the discovery of new treatments for an endemic infectious disease using locally sourced African medicinal plants.
Description: Copyright © 2018 Gertrude Kyere-Davies et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/123456789/11305
Appears in Collections:College of Health Sciences

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