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|Title: ||Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni|
|Authors: ||Kyere-Davies, Gertrude|
Boakye, Yaw Duah
Suzuki, Brian M.
Caffrey, Conor R.
|Issue Date: ||2018|
|Citation: ||Journal of Parasitology Research, Volume 2018, Article ID 9431467, 7 pages|
|Abstract: ||Schistosomiasis is a disease caused by a flatworm parasite that infects people in tropical and subtropical regions of Sub-Saharan
Africa, South America, China, and Southeast Asia. The reliance on just one drug for current treatment emphasizes the need for
new chemotherapeutic strategies. The aimof this study was to determine the phenotypic effects of extracts and fractions of leaf and
stem bark of Erythrophleum ivorense (family Euphorbiaceae), a tree that grows in tropical parts of Africa, on two developmental
stages of Schistosoma mansoni, namely, postinfective larvae (schistosomula or somules) and adults. Methanol leaf and stem bark
extracts of E. ivorense were successively fractionated with acetone, petroleum ether, ethyl acetate, and methanol. These fractions
were then incubatedwith somules at 0.3125 to 100 𝜇g/mL and with adults at 1.25 𝜇g/mL. The acetone fractions of both themethanol
leaf and bark of E. ivorense were most active against the somules whereas the petroleum ether fractions showed least activity. For
adult parasites, the acetone fraction of methanol bark extract also elicited phenotypic changes. The data arising provide the first
step in the discovery of new treatments for an endemic infectious disease using locally sourced African medicinal plants.|
|Description: ||Copyright © 2018 Gertrude Kyere-Davies et al.This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
|Appears in Collections:||College of Health Sciences|
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