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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11809

Title: Analogues of disulfdes from allium stipitatum demonstrate potent anti-tubercular activities through drug efux pump and bioflm inhibition
Authors: Danquah, Cynthia A.
Kakagianni, Eleftheria
Khondkar, Proma
Maitra, Arundhati
Rahman, Mukhlesur
Evangelopoulos, Dimitrios
McHugh, Timothy D.
Stapleton, Paul
Malkinson, John
Bhakta, Sanjib
Gibbons, Simon
Issue Date: 18-Jan-2018
Publisher: Scientific Reports
Citation: Scientific Reports | (2018) 8:1150
Abstract: Disulfdes from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation of appropriate thiols using S-methyl methanethiosulfonate, exhibited antimicrobial activity, with one compound inhibiting the growth of Mycobacterium tuberculosis at 17 µM (4 mg L−1) and other compounds inhibiting Escherichia coli and multi-drug-resistant (MDR) Staphylococcus aureus at concentrations ranging between 32–138 µM (8–32 mg L−1). These compounds also displayed moderate inhibitory efects on Klebsiella and Proteus species. Whole-cell phenotypic bioassays such as the spotculture growth inhibition assay (SPOTi), drug efux inhibition, bioflm inhibition and cytotoxicity assays were used to evaluate these compounds. Of particular note was their ability to inhibit mycobacterial drug efux and bioflm formation, while maintaining a high selectivity towards M. tuberculosis H37Rv. These results suggest that methyl disulfdes are novel scafolds which could lead to the development of new drugs against tuberculosis (TB).
Description: An article published by Scientific Reports | (2018) 8:1150 available at DOI:10.1038/s41598-017-18948-w
URI: http://hdl.handle.net/123456789/11809
Appears in Collections:College of Health Sciences

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