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|Title: ||Analogues of disulfdes from allium stipitatum demonstrate potent anti-tubercular activities through drug efux pump and bioflm inhibition|
|Authors: ||Danquah, Cynthia A.|
McHugh, Timothy D.
|Issue Date: ||18-Jan-2018|
|Publisher: ||Scientific Reports|
|Citation: ||Scientific Reports | (2018) 8:1150|
|Abstract: ||Disulfdes from Allium stipitatum, commonly known as Persian shallot, were previously reported to
possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation
of appropriate thiols using S-methyl methanethiosulfonate, exhibited antimicrobial activity, with
one compound inhibiting the growth of Mycobacterium tuberculosis at 17 µM (4 mg L−1) and other
compounds inhibiting Escherichia coli and multi-drug-resistant (MDR) Staphylococcus aureus at
concentrations ranging between 32–138 µM (8–32 mg L−1). These compounds also displayed moderate
inhibitory efects on Klebsiella and Proteus species. Whole-cell phenotypic bioassays such as the spotculture growth inhibition assay (SPOTi), drug efux inhibition, bioflm inhibition and cytotoxicity assays
were used to evaluate these compounds. Of particular note was their ability to inhibit mycobacterial
drug efux and bioflm formation, while maintaining a high selectivity towards M. tuberculosis H37Rv.
These results suggest that methyl disulfdes are novel scafolds which could lead to the development of
new drugs against tuberculosis (TB).|
|Description: ||An article published by Scientific Reports | (2018) 8:1150 available at DOI:10.1038/s41598-017-18948-w|
|Appears in Collections:||College of Health Sciences|
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