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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11845

Title: Clinical Efficacy of Combination of Rifampin and Streptomycin for Treatment of Mycobacterium ulcerans Disease
Authors: Sarfo, Fred Stephen
Phillips, Richard O.
Asiedu, Kingsley
Ampadu, Edwin
Bobi, Nana
Issue Date: Sep-2010
Publisher: Antimicrobial Agents and Chemotherapy
Citation: Antimicrobial Agents and Chemotherapy p. 1161–1166
Abstract: We have evaluated the clinical efficacy of the combination of oral rifampin at 10 mg/kg of body weight and intramuscular streptomycin at 15 mg/kg for 8 weeks (RS8), as recommended by the WHO, in 160 PCRconfirmed cases of Mycobacterium ulcerans disease. In 152 patients (95%) with all forms of disease from early nodules to large ulcers, with or without edema, the lesions healed without recourse to surgery. Eight patients whose ulcers were healing poorly had skin grafting after completion of antibiotics. There were no recurrences among 158 patients reviewed at the 1-year follow-up. The times to complete healing ranged from 2 to 48 weeks, according to the type and size of the lesion, but the average rate of healing (rate of reduction in ulcer diameter) varied widely. Thirteen subjects had positive cultures for M. ulcerans during or after treatment, but all the lesions healed without further antibiotic treatment. Adverse events were rare. These results confirm the efficacy of RS8 delivered in a community setting.
Description: An article by Antimicrobial Agents and Chemotherapy
URI: http://hdl.handle.net/123456789/11845
Appears in Collections:College of Health Sciences

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