Dynamics of the Cytokine Response to Mycobacterium ulcerans during Antibiotic Treatment for M. ulcerans Disease (Buruli Ulcer) in Humans
No Thumbnail Available
Date
2009-01
Authors
Sarfo, Fred Stephen
Phillips, Richard Odame
Ampadu, E.
Sarpong, F.
Adentwe, E.
et.al
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
We have studied the evolution of the gamma interferon (IFN- ) and interleukin 10 (IL-10) responses after
Mycobacterium ulcerans sonicate stimulation of whole blood from patients with early M. ulcerans lesions during
treatment with rifampin and streptomycin for 8 weeks. Among the 26 patients, secretion of IFN- increased
during treatment, with a significant increase at 4 weeks and a further increase after 8 weeks overall. The
increase was more rapid in patients with large or ulcerative lesions, becoming significant by 4 weeks. For small
lesions, there was only a minor increase, which did not reach significance. There was no significant change in
the median IL-10 response during antibiotic therapy, and there was no inverse correlation between IFN- and
IL-10 responses. These results demonstrate that an IFN- secretory response to M. ulcerans developed,
independently of IL-10 secretion, in patients whose M. ulcerans disease healed during antibiotic therapy.
Description
An article by American Society for Microbiology
Keywords
Citation
American Society for Microbiology Vol. 16, No. 1