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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11864

Title: Loop-Mediated Isothermal Amplification for Laboratory Confirmation of Buruli Ulcer Disease—Towards a Point-of-Care Test
Authors: Beissner, Marcus
Phillips, Richard O.
Battke, Florian
Bauer, Malkin
Badziklou, Kossi
et. al
Issue Date: 13-Nov-2015
Publisher: PLOS Neglected Tropical Diseases
Citation: PLoS Negl Trop Dis 9(11): e0004219. doi:10.1371/journal.pntd.0004219
Abstract: As the major burden of Buruli ulcer disease (BUD) occurs in remote rural areas, development of point-of-care (POC) tests is considered a research priority to bring diagnostic services closer to the patients. Loop-mediated isothermal amplification (LAMP), a simple, robust and cost-effective technology, has been selected as a promising POC test candidate. Three BUD-specific LAMP assays are available to date, but various technical challenges still hamper decentralized application. To overcome the requirement of cold-chains for transport and storage of reagents, the aim of this study was to establish a dry-reagentbased LAMP assay (DRB-LAMP) employing lyophilized reagents.
Description: An article published by PLOS Neglected Tropical Diseases
URI: http://hdl.handle.net/123456789/11864
Appears in Collections:College of Health Sciences

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