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|Title: ||A re-evaluation of the origin of hepatitis C virus genotype 2 in West Africa|
|Authors: ||Phillips, Richard O.|
Purdy, Michael A.
Forbi, Joseph C.
Layden, Jennifer E.
|Issue Date: ||2015|
|Publisher: ||Journal of General Virology|
|Citation: ||Journal of General Virology (2015), 96, 2157–2164|
|Abstract: ||Hepatitis C virus (HCV) is classified into seven genotypes based on genetic diversity, and most
genotypes have been found in Africa. Infections with HCV genotype 2 (HCV2) are most
prevalent in West Africa and it was suggested that HCV2 originated in West Africa. To better
understand the evolutionary epidemiology of HCV2 in Africa, we examined new NS5B
sequences of HCV2 strains obtained from Coˆ te d’Ivoire, Ghana and Nigeria sequenced at the
Centers for Disease Control and Prevention with those available from West, North and Central
Africa. Bayesian phylogeographic analysis using a discrete trait model showed that Ghana was
the most likely geographical region for the origin of HCV2. Spread of HCV2 from Ghana did not
appear to be through diffusion to adjacent countries along the coast. Rather, it was transmitted
from Ghana to many distant countries in Africa, suggesting that certain routes of geographical
dissemination were historically more efficient than mere proximity and that the HCV2 epidemic
history in West Africa is extremely complex.|
|Description: ||An article published by Journal of General Virology and available at DOI 10.1099/vir.0.000153
|Appears in Collections:||College of Health Sciences|
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