Theses / Dissertations >
College of Health Sciences >
Please use this identifier to cite or link to this item:
|Title: ||Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus|
|Authors: ||Phillips, Richard O.|
Tabah, Earnest Njih
|Issue Date: ||Jul-2019|
|Publisher: ||Elsevier Ltd|
|Citation: ||Elsevier Ltd Vol 7|
|Abstract: ||Background Buruli ulcer can cause disfigurement and long-term loss of function. It is underdiagnosed and underreported,
and its current distribution is unclear. We aimed to synthesise and evaluate data on Buruli ulcer prevalence
Methods We did a systematic review of Buruli ulcer prevalence and used an evidence consensus framework to
describe and evaluate evidence for Buruli ulcer distribution worldwide. We searched PubMed and Web of Science
databases from inception to Aug 6, 2018, for records of Buruli ulcer and Mycobacterium ulcerans detection, with no
limits on study type, publication date, participant population, or location. English, French, and Spanish language
publications were included. We included population-based surveys presenting Buruli ulcer prevalence estimates, or
data that allowed prevalence to be estimated, in the systematic review. We extracted geographical data on the
occurrence of Buruli ulcer cases and M ulcerans detection from studies of any type for the evidence consensus
framework; articles that did not report original data were excluded. For the main analysis, we extracted prevalence
estimates from included surveys and calculated 95% CIs using Byar’s method. We included occurrence records,
reports to WHO and the Global Infectious Diseases and Epidemiology Network, and surveillance data from Buruli
ulcer control programmes in the evidence consensus framework to grade the strength of evidence for Buruli ulcer
endemicity. This study is registered with PROSPERO, number CRD42018116260.
Findings 2763 titles met the search criteria. We extracted prevalence estimates from ten studies and occurrence data
from 208 studies and five unpublished surveillance datasets. Prevalence estimates within study areas ranged from
3·2 (95% CI 3·1–3·3) cases per 10 000 population in Côte d’Ivoire to 26·9 (23·5–30·7) cases per 10 000 population in
Benin. There was evidence of Buruli ulcer in 32 countries and consensus on presence in 12.
Interpretation The global distribution of Buruli ulcer is uncertain and potentially wider than currently recognised.
Our findings represent the strongest available evidence on Buruli ulcer distribution so far and have many potential
applications, from directing surveillance activities to informing burden estimates.
Funding AIM Initiative.|
|Description: ||An article published by Elsevier Ltd|
|Appears in Collections:||College of Health Sciences|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.