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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12066

Title: Antiplasmodial Securinega Alkaloids from Phyllanthus fraternus: Discovery of Natural (+)-Allonorsecurinine
Authors: Dickson, Rita A.
Komlaga, Gustav
Genta-Jouve, Grégory
Cojean, Sandrine
Mensah, Merlin L. K.
Loiseau, Philippe M.
Champy, Pierre
Beniddir, Mehdi A.
Keywords: Allonorsecurinine
NMR shift calculation
Issue Date: Aug-2017
Publisher: Tetrahedron Letters
Citation: Tetrahedron Letters, Volume 58, Issue 38
Abstract: The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration of the new compound were elucidated on the basis of extensive spectroscopic analysis, optical rotation, and GIAO NMR shift calculation followed by CP3 analysis. The antiplasmodial activity of these compounds was evaluated against chloroquineresistant (W2) and -sensitive (3D7) strains of Plasmodium falciparum. Among them, entnorsecurinine (2) and (+)-allonorsecurinine (1) showed the strongest activity (IC50: 1.14±0.32 and 2.57 ± 0.53 µM) respectively, against W2 but one of the weakest against 3D7.
Description: This article is published in Tetrahedron Letters and also available at https://doi.org/10.1016/j.tetlet.2017.08.045
URI: 10.1016/j.tetlet.2017.08.045
Appears in Collections:College of Health Sciences

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