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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12071

Title: In Vitro Evaluation of Effects of Two Ghanaian Plants Relevant to Wound Healing
Authors: Mensah, Y Abraham
Houghton, Peter J.
Dickson, Rita A.
Fleischer, T. C.
Heinrich, M.
Bremner, P.
Keywords: Commelina diffusa
Spathodea campanulata
ringworm fungi
wound healing
; lipid peroxidation
Issue Date: Apr-2006
Citation: PHYTOTHERAPY RESEARCH, 20, 941–944
Abstract: Commelina diffusa and Spathodea campanulata are used as wound‐healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC50 value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC‐5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 µg/mL and 10 µg/mL. The extracts showed no inhibition of NF‐κB at 100 µg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents. Copyright © 2006 John Wiley & Sons, Ltd.
Description: This article is published in PHYTOTHERAPY RESEARCH and also available at DOI: 10.1002/ptr.1978
URI: 10.1002/ptr.1978
Appears in Collections:College of Health Sciences

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