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| Title: | In Vitro Evaluation of Effects of Two Ghanaian Plants Relevant to Wound Healing |
| Authors: | Mensah, Abraham Y.
Houghton, Peter J.
Dickson, Rita A.
Fleischer, T. C.
Heinrich, M.
Bremner, P. |
| Keywords: | Commelina diffusa
Spathodea campanulata
ringworm fungi
bacteria
wound healing
lipid peroxidation |
| Issue Date: | Apr-2017 |
| Publisher: | PHYTOTHERAPY RESEARCH |
| Citation: | PHYTOTHERAPY RESEARCH, 20, 941–944 |
| Abstract: | Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional
medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark
showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against
Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC50 value
of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant
activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between
1 µg/mL and 10 µg/mL. The extracts showed no inhibition of NF-κB at 100 µg/mL. The antioxidant activities
and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant
and antiseptic effects of its constituents. Copyright © 2006 John Wiley & Sons, Ltd. |
| Description: | This article is published in PHYTOTHERAPY RESEARCH and also available at DOI: 10.1002/ptr.1978 |
| URI: | 10.1002/ptr.1978
http://hdl.handle.net/123456789/12092 |
| Appears in Collections: | College of Health Sciences
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