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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12288

Title: Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment
Authors: Amidu, Nafiu
Antuamwine, Benedict Boateng
Akilla, Martin Awe
Owiredu, William Kwame Boakye Ansah
Addai-Mensah, Otchere
et. al
Keywords: Preeclampsia,
Gestational Hypertension,
Differential Leucocytes Count,
Neutrophil-to-Lymphocyte Ratio,
Risk Assessment,
Stillbirth
Issue Date: 14-Feb-2020
Publisher: Science Publishing Group
Citation: Nafiu Amidu, Benedict Boateng Antuamwine, Martin Awe Akilla, William Kwame Boakye Ansah Owiredu, Otchere Addai-Mensah, Peter Paul Dapare, Eric Mishio Bawa. Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment. American Journal of Laboratory Medicine. Vol. 5, No. 1, 2020, pp. 32-41. doi: 10.11648/j.ajlm.20200501.15
Abstract: PIH accounts significantly for maternal and perinatal mortality, especially in rural communities. The sudden onset of PIH and the lack of definitive case management is worrisome. The study analysed differential leucocytes count on PIH outcomes. This is a case-control study of 40 PIH (8 GH, 16 PE and 16 EC) and 60 normotensive women who visited the Bolgatanga Regional Hospital, Ghana. Data on socio-demographics, clinical history and laboratory evaluations on blood and placental tissues were collected and analysed. Lymphocytes count was markedly increased in PIH women, while total leucocytes, neutrophils and NLR were significantly decreased. Lymphocytes count increased with severity of PIH (p=0.0037). A correlation (r=-0.9565, p<0.0001) between lymphocyte and neutrophil counts was observed among PIH subjects. Oxidative stress was more associated with PIH compared to controls. Stillbirths was associated with PIH mothers with high leucocytes count. NLR (AUC; 0.857, p<0.0001) and lymphocytes count (AUC; 0.822, p<0.0001) were optimal for prognosis of PIH. Wide variations in NLR and lymphocytes count during pregnancy necessitates urgent attention.
Description: An article published by Science Publishing Group and also available by doi: 10.11648/j.ajlm.20200501.15
URI: http://hdl.handle.net/123456789/12288
Appears in Collections:College of Health Sciences

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