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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12296

Title: Renal insufficiency in Ghanaian HIV infected patients: need for dose adjustment
Authors: Owiredu, WKBA
Quaye, L
Amidu, N
Addai-Mensah, O
Keywords: Antiretroviral,
predictive equation,
renal function,
Issue Date: 2013
Publisher: Makerere University Medical School (Uganda)
Citation: African Health Sciences 2013; (1): 101 - 111 http://dx.doi.org/10.4314/ahs.v13i1.14
Abstract: Background: Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency. Objective: To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients. Method: In estimating renal insufficiency in Ghanaian HIV-infected patients, GFR for 276 HAART-naïve patients and 166 patients on HAART was estimated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI estimating equations. Results: Females outnumbered males by 3 to 1 in the HAART-naïve group and 4 to 1 in subjects on HAART. The prevalence of renal insufficiency calculated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI equations was 8.7%, 9.1% and 8.7% in HAART-naïve patients; 14.5%, 12.6% and 12.6% in patients on HAART; 7.7%, 11.5% and 11.5% in HAARTnaïve males; 10.8%, 8.1% and 8.1% in males on HAART; 9.1%, 8.0% and 7.5% in HAART-naïve females and 15.5%, 14.0% and 14.0% in females on HAART. The CKD-EPI equation yielded lower bias when compared to the Cockcroft-Gault and 4v-MDRD equations. Conclusion: Renal insufficiency is not uncommon among HIV infected Ghanaian patients. A significant proportion (10 to 11%) will require ARV dose adjustment at the time of initiating therapy or sometime during on-going therapy.
Description: An article published by Makerere University Medical School (Uganda)and also available at http://dx.doi.org/10.4314/ahs.v13i1.14
URI: http://hdl.handle.net/123456789/12296
Appears in Collections:College of Health Sciences

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