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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12301

Title: Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans
Authors: Addai-Mensah, Otchere
Gyamfi, Daniel
Amponsah, Francis Agyei
Annani-Akollor, Max Efui
Danquah, Kwabena Owusu
et. al
Issue Date: 2019
Publisher: Hindawi
Citation: Hindawi e Scientific World Journal Volume 2019, Article ID 5398732, 9 pages https://doi.org/10.1155/2019/5398732
Abstract: Te pathophysiology of malaria-related anaemia is not fully understood although increased destruction of parasitized and nonparasitized erythrocytes, as well as inadequate erythropoiesis, has been proposed. Circulating antierythropoietin (antiEPO) antibodies have also been implicated in malaria and malaria-related anaemia in mice. However, studies on this association have not been investigated in humans. Tis study therefore determined the prevalence of anti-EPO antibody production and assessed its association with malaria and malaria-related anaemia in humans. Methods. A total of 86 children aged 1-10 years (57 children with malaria serving as the case group and 29 healthy children serving as control), all residents of Duayaw Nkwanta, Ghana, were recruited for this case-control study. Venous blood was collected for thick and thin flms for malaria microscopy, full blood count by automated haematology analyzer, and antierythropoietin antibody and erythropoietin estimation by sandwich ELISA method. Results. Out of the 86 participants recruited, only 3 (3.5%) were positive for anti-EPO antibody; 2.3% of the case group; and 1.2% of the control group. Tere was no association between the cases and the controls in the production of antiEPO antibodies. Erythropoietin concentration was signifcantly higher in malaria-related anaemic subjects (p=0.032). Conclusion. Antierythropoietin antibodies are not associated with malaria infection and malaria-related anaemia in humans. Erythropoietin concentration is associated with malaria-related anaemia.
Description: An article published by Hindawi and also available at https://doi.org/10.1155/2019/5398732
URI: http://hdl.handle.net/123456789/12301
Appears in Collections:College of Health Sciences

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