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|Title: ||Determination of Haematological Reference Ranges in Healthy Adults in Three Regions in Ghana|
|Authors: ||Addai-Mensah, Otchere|
Duneeh, Richard Vikpebah
Danquah, Kwabena O.
Annani-Akollor, Max E.
|Issue Date: ||5-Feb-2019|
|Citation: ||Hindawi BioMed Research International Volume 2019, Article ID 7467512, 6 pages https://doi.org/10.1155/2019/7467512|
|Abstract: ||Laboratory results interpretation for diagnostic accuracy and clinical decision-making in this period of evidence-based medicine
requires cut-of values or reference ranges that are refective of the geographical area where the individual resides. Several studies
have shown signifcant diferences between and within populations, emphasizing the need for population-specifc reference ranges.
Tis cross-sectional experimental study sought to establish the haematological reference values in apparently healthy individuals
in three regions in Ghana. Study sites included Nkenkaasu, Winneba, and Nadowli in the Ashanti, Central, and Upper West
regions of Ghana, respectively. A total of 488 healthy participants were recruited using the Clinical and Laboratory Standards
Institute (United States National Consensus Committee on Laboratory Standards, NCCLS) Guidance Document C28A2. Medians
for haematological parameters were calculated and reference values determined at 2.5th and 97.5th percentiles and compared with
Caucasian values adopted by our laboratory as reference ranges and values from other African and Western countries. RBC count,
haemoglobin, and haematocrit (HCT) were signifcantly higher in males compared to females. Tere were signifcant intraregional
and interregional as well as international variations of haematological reference ranges in the populations studied. We conclude
that, for each geographical area, there is a need to establish geography-specifc reference ranges if accurate diagnosis and concise
clinical decisions are to be made.|
|Description: ||An article published by Hindawi and also available at
|Appears in Collections:||College of Health Sciences|
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