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|Title: ||Assessment of platelet indices and platelet activation markers in children with Plasmodium falciparum malaria|
|Authors: ||Asare, Renate|
Owusu Danquah, Kwabena
|Keywords: ||Platelet membrane glycoproteins,|
|Issue Date: ||Dec-2020|
|Publisher: ||BioMed Central|
|Citation: ||Asare et al. Malar J (2020) 19:143 https://doi.org/10.1186/s12936-020-03218-4|
|Abstract: ||Background: Plasmodium falciparum malaria remains one of the world’s major infectious diseases that cause most
morbidity and mortality, particularly in children. In Ghana, most children below the ages of 5 years depending on
the severity of the infection often lose their lives. However, it is still debatable why infection with falciparum malaria
contributes to thrombocytopenia.
Methods: This study sought to investigate the expression of the various platelet indices and activation markers in
children with falciparum malaria. Platelet indices (Platelet count [PLT], Plateletcrite [PCT], Mean Platelet Volume [MPV],
Platelet Distribution Width [PDW] and Platelet-Large Cell Ratio [P-LCR]) and platelet surface membrane glycoproteins
(GPIIb/IIIa [PAC-1], P-selectin [CD62p] and GPIV [CD36]) expressions were determined in children with falciparum
malaria (cases) and healthy children (controls) using automated blood cell analysis and flow cytometry techniques,
Results: Except for P-LCR, all the other platelet indices (PLT, MPV, PDW, and PCT) were significantly lower in the cases
than the controls (P < 0.05). Also, it was observed that the level of expression of the activation markers; PAC 1 and
CD62p showed a significant (P < 0.05) decreased before and after activation in falciparum malaria cases than in the
controls. On the contrary, CD36 expression in the controls did not differ significantly (p > 0.05) from the malaria cases.
Platelet activation markers were known to be associated with increased risk of falciparum malaria with the mean
fluorescence intensity of PAC1 (Odds Ratio [OR] 34.0, Relative Risk [RR] 4.47, 95% Confidence Interval [CI] 4.904–235.7;
p < 0.0001) and CD36 (OR 4.2, RR 1.82, 95% CI 0.9824–17.96; p = 0.04). Moreover, the percentage expression of CD62p
(OR 4.0, RR 1.80, 95% CI 0.59–27.24; p = 0.19) was also observed to be probably associated with increased risk of falciparum
malaria although not statistically significant (p > 0.05).
Conclusion: Plasmodium falciparum malaria has been known to be associated with platelet activation markers,
which probably contributes to thrombocytopenia.|
|Description: ||An article of published by BioMed Central and also available at https://doi.org/10.1186/s12936-020-03218-4|
|Appears in Collections:||College of Health Sciences|
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