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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12308

Title: Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma
Authors: Asare, Renate
Opoku- Okrah, Clement
Danquah, Kwabena Owusu
Opare-Sem, Ohene
Addai-Mensah, Otchere
et. al
Keywords: Platelet membrane glycoproteins
Platelet indices
Burkitt lymphoma
Flow cytometry
Issue Date: 1-Sep-2019
Publisher: 9 Elsevier Ltd.
Citation: 9 Elsevier Ltd. https://doi.org/10.1016/j.leukres.2019.106189
Abstract: Platelet activation and functional changes in some haematological malignancies have been investigated with little or no known documentation on Burkitt lymphoma (BL). Abnormalities of platelets contribute to either haemorrhage or thrombotic episodes which are life-threatening in patients with BL. Thus, the study aimed at investigating the various platelet indices and platelet membrane glycoproteins in childhood Burkitt lymphoma. Platelet surface membrane glycoproteins (GPIIb/IIIa, P-selectin and GPIV using PAC 1, CD62p and CD36 monoclonal antibodies respectively) and platelet indices (Platelet Count [PLT], Plateletcrite [PCT], Mean Platelet Volume [MPV], Platelet Distribution Width [PDW] and Platelet Large Cell Ratio [P-LCR]) were determined in children with Burkitt lymphoma and healthy children (normal controls) based on flow cytometry and automated blood cell analysis techniques. PLT and PCT were higher in BL cases than in the normal controls with a significant difference in the PLT (P = 0.02). On the contrary, we observed a significant (p < 0.05) lower levels in the other platelet indices (MPV, PDW and P-LCR) in children with BL than the controls. With the exception of CD62 P, the other platelet membrane glycoproteins examined showed a decreased level of expression before and after the addition of an Adenosine -5- diphosphate (ADP) in cases of BL. In addition, PAC-1 was probably known to be associated with Burkitt Lymphoma (Odds Ratio [OR] 6.67, Relative Risk [RR] 3.13, 95% CI 1.06–9.21; p = 0.02). Finally, oral bleeding was observed to be the commonest bleeding episodes associated with childhood BL. Flow cytometry analysis and cell counting techniques of platelet assessment has described the expression of the platelet membrane glycoproteins and parameters in children with Burkitt lymphoma. Thus, children with Burkitt lymphoma tend to show normal to increased level of circulatory platelets but decreased platelet membrane glycoprotein expressions and platelet dysfunction.
Description: An article published by Elsevier Ltd.and also available at https://doi.org/10.1016/j.leukres.2019.106189
URI: http://hdl.handle.net/123456789/12308
Appears in Collections:College of Health Sciences

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