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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12309

Title: Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
Authors: Kaminski, Lea-Christina
Riehn, Mathias
Abel, Annemieke
Steeg, Christiane
Addai-Mensah, Otchere
et. al
Keywords: granzyme B, CD8+ T cells,
malaria,
severe malaria,
Plasmodium falciparum
Issue Date: 11-Dec-2019
Publisher: Frontiers
Citation: Kaminski L-C, Riehn M, Abel A, Steeg C, Yar DD, Addai-Mensah O, Aminkiah F, Owusu Dabo E, Jacobs T and Mackroth MS (2019) Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria. Front. Immunol. 10:2917. doi: 10.3389/fimmu.2019.02917
Abstract: In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8+ T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8+ T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8+ T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8+ T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B+ CD8+ T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8+ T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8+ T cells in the development of malaria complications in humans.
Description: An article published by Frontiers and also available at doi: 10.3389/fimmu.2019.02917
URI: http://hdl.handle.net/123456789/12309
Appears in Collections:College of Health Sciences

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