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|Title: ||Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana|
|Authors: ||Bortey-Sam, Nesta|
Nakayama, Shouta M.M.
Asante, Kwadwo A.
|Issue Date: ||2017|
|Publisher: ||Environmental Pollution|
|Citation: ||Environmental Pollution,|
|Abstract: ||Heavy metals and metalloids contamination in soils, water, food and livers of wild rats have been studied
in Kumasi, Ghana and despite the estimated risks to residents, there is no epidemiological study to
ascertain these projections. In addition, the World Health Organization and International Agency for
Research on Cancer have reported an increase in respiratory diseases and cancers, in Ghana. The study's
purpose was therefore to explore the potential associations between metal exposure and occurrences of
respiratory diseases, lipid peroxidation and/or DNA damage to different age groups and sexes in Kumasi.
Human urine was collected from the general population in urban and control sites in Kumasi and nine
metals were measured in each sample. Results showed that although Zn was the most abundant total
urinary As concentration was higher in 83% of samples compared to reference values. Urinary concentrations of metals, malondialdehyde (MDA) and 8-hydroxy-2-deoxy-guanosine (8-OHdG) were higher in
urban sites compared to the control site. Based on the results obtained, there was no significant correlation between urinary metals and age. However, urinary Cd and MDA were highest in age groups 61e85
and 3e20 years, respectively. Significantly higher levels of urinary Co, As and Cd were detected in female
participants. The study revealed that exposure to As was significantly associated with increased odds of
asthma (odds ratio (OR) ¼ 2.76; CI: 1.11e6.83) and tachycardia (OR ¼ 3.93; CI: 1.01e15.4). Significant
association was observed between urinary metals and MDA and 8-OHdG indicating possibility of lipid
peroxidation and/or DNA damage in Kumasi residents.|
|Description: ||This article is published in Environmental Pollution and also available at
|Appears in Collections:||College of Science|
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