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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12367

Title: Safety Evaluation of BF001, an Anti-diabetic Herbal Preparation in Sprague-Dawley Rats
Authors: Owiredu, W.K.B.A.
Takyi, N.K.
Okine, L.K.N.
Sittie, A.A.
Addai-Mensah, O.
et. al
Keywords: Toxicity,
Bridelia ferruginea,
Issue Date: 13-Mar-2011
Publisher: West African Journal of Pharmacy
Citation: West African Journal of Pharmacy (2011) 22 (1) 49 - 57
Abstract: Background: "BF001" is a herbal preparation made from the leaves of Bridelia ferruginea. Despite its prolonged use in treating diabetes mellitus, there is no empirical evidence of its safety as a hypoglycaemic agent. Objectives: This study evaluated the acute and chronic toxicity of 'BF001' with the view to determining the LD50 and toxic effects on specific organs after prolonged administration in male Spraque-Dawley rats. -1 Methods: Acute toxicity was carried out within 14 days; a single high dose of 5000 mg kg body weight was administered orally to a group of 8 rats to determine LD . Chronic toxicity was also carried out over a period of 6 50 -1 -1 months (180 days) at the normal therapeutic dose level (41 mg kg ) and ten times the normal dose (410 mg kg ). Results: There were no significant differences found in most of the haematological, urine chemistry, serum biochemical parameters and relative organ weight. It, however, caused a significant decrease in pentobarbitone -1 induced sleeping time. The oral LD of 'BF001' is above 5000 mg kg body weight. 50 Conclusion: 'BF001' had no overt organ specific toxicity but may modulate the production and/or the activity of certain microsomal monooxygenases which may lead to drug-drug interactions if the test preparation is taken concurrently with other medicinal preparations.
Description: An article published by West African Journal of Pharmacy
URI: http://hdl.handle.net/123456789/12367
Appears in Collections:College of Health Sciences

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