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|Title: ||Anti-Inflammatory, Antioxidant, and Anthelmintic Activities of Ocimum basilicum (Sweet Basil) Fruits|
|Authors: ||Akoto, Clement Osei|
Boakye, Yaw Duah
Naazo, Abdulai A.
Adomah, Derrick H.
|Issue Date: ||23-May-2020|
|Citation: ||Clement Osei Akoto et al. *is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Abstract: ||Basil (Ocimum basilicum Linn.) is a plant that has found use in traditional medicine and household remedy against human ailments.
*e present study aimed at investigating hexane and ethanol fruit extracts of Ocimum basilicum Linn. for their phytoconstituents and
anti-inflammatory, antioxidant, and anthelmintic activities. Phytochemical screenings were performed using standard protocols.
Anti-inflammatory activities were assessed using the egg albumin denaturation method, while the antioxidant activities of the extracts
were determined using DPPH scavenging, total antioxidant capacity (TAC), and hydrogen peroxide (H2O2) assays. In vitro anthelmintic
activity of both extracts was investigated against Eudrilus eugeniae(Earthworms). Column chromatography was employed
to separate the least polar fraction A, using hexane as the mobile phase, which was analyzed using FTIR analysis. *e preliminary
phytochemical screening revealed the presence of alkaloids, phenols, saponins, glycosides, steroids, tannins, terpenoids, and flavonoids.
*e hexane and ethanol extracts exhibited high concentration-dependent anti-inflammatory activities, with their percentage
inhibitions being 34.0 ± 0.01 and 17.6 ± 0.04 μg/mL, respectively. *e hexane extract showed a higher concentration-dependent
antioxidant activity (IC50 of 14.17 ± 1.15 μg/mL) compared to the ethanol extract (IC50 > 100.0 μg/mL) for the DPPH assay. *e IC50
values of ethanol and hexane extracts were 623.5 ± 0.27 and >1000.0 μg/mL, respectively, for the H2O2 scavenging assay. TAC was
determined to be 37.48 ± 0.09 and 18.81 ± 0.12 gAAE/100 g for ethanol and hexane extracts, respectively. Both extracts showed a
higher concentration-dependent anthelmintic activity. Increasing the concentration increased the helmintic potency of the extracts.
*e results indicate that both hexane and ethanol extracts of Ocimum basilicum Linn. exhibit anti-inflammatory, antioxidant, and
anthelmintic activities and support the traditional usage of this plant.|
|Description: ||An article published by Hindawi and also available at
|Appears in Collections:||College of Science|
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