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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12384

Title: Harnessing Glycal-Epoxide Rearrangements: The Generation of the AB, EF, and IJ Rings of Adriatoxin
Authors: Akoto, Clement Osei
Rainier, Jon D.
Keywords: enols
epoxidation
metathesis
rearrangement
titanium
Issue Date: 2008
Publisher: NIH Public Access
Citation: NIH Public Access.,DOI: 10.1002/anie.200803791
Abstract: The marine ladder toxin class of natural products has generated considerable interest from the synthetic and biomedical communities because of their fascinating structures and biological activities.[1, 2] This group includes a target that has recently become of interest to us, adriatoxin (Scheme 1), a polyether toxin isolated by Fattorusso and coworkers from the digestive gland of the Adriatic mussel Mytilus galloprovincialis. [3–5] Synthetically, our fascination with adriatoxin came out of an interest in determining whether our recently described coupling protocol, which leads to the pairing of two subunits and the generation of two additional rings, would enable us to carry out a convergent synthesis of the ten-ring system from three bicyclic precursors representing the AB ring (1), the EF ring (2), and the IJ ring
Description: An article published by NIH Public Access and also available at DOI: 10.1002/anie.200803791
URI: http://hdl.handle.net/123456789/12384
Appears in Collections:College of Science

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