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|Title: ||The effect of alpha (+) -thalassaemia on P. falciparum malaria parasitaemia in children attending Komfo Anokye Teaching Hospital|
|Authors: ||Franklin, K.|
Sylverken, Augustina Angelina
|Issue Date: ||2011|
|Publisher: ||International Journal of Biomedical Laboratory Science|
|Citation: ||International Journal of Biomedical Laboratory Science (IJBLS) 2011 Vo1 1:7-14|
|Abstract: ||Malaria reportedly accounts for 10% of Africa’s disease burden and about 90% of the global morbidity
and mortality affecting mostly children under 5 years old. Previous studies have ex-pressed
varied opinion on the protection from severe Plasmodium falciparum malaria by α+-thalassaemia. A
random cross-sectional sampling of 456 children at the Komfo Anokye Teach-ing Hospital (KATH),
Kumasi, Ghana were tested for malaria parasite, complete blood count (CBC), serum ferritin, and
α-globin genotype. Alpha (+)-thalassaemic children recorded a sig-nificantly lower (28,705/μL)
mean parasite density (MPD) compared to non-α-thalassaemic children (35,483/μL) (p<0.0001).
The homozygotes, α+-thalassaemia, recorded a significantly lower (691/μL) MPD compared to
26,350/μL for the heterozygotes and 35,483/μL for the non-α-thalassaemic children (p = 0.0001).
Alpha (+)-thalassaemia was hypothesized to protect against malaria via a reduction in the parasite
density. The homozygous α+-thalassaemias were more protective than the heterozygous. Microcytic
hypochromic anaemia was found in 141 (59%) of the subjects of which 71 were α+-thalassaemia.
Alpha (+)-thalassaemia was shown to be a possibly key contributor to microcytic hypochromic
anaemia amongst cases that were suspected of iron deficiency. Suspected iron deficiency cases
should therefore be screened for α-thalassaemia to avoid the unnecessary administration of iron
|Description: ||An article published by International Journal of Biomedical Laboratory Science|
|Appears in Collections:||College of Science|
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