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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12542

Title: Aetiology of viral hepatitis among jaundiced patients presenting to a tertiary hospital in Ghana
Authors: Owusu, Michael
Bonney, Joseph Kofi
Sylverken, Augustina Angelina
Mawuli, Gifty
Okyere, Kennedy
et. al
Issue Date: 12-Sep-2018
Publisher: PLoS ONE
Citation: Owusu M, Bonney JK, Annan AA, Mawuli G, Okyere K, Mutocheluh M, et al. (2018) Aetiology of viral hepatitis among jaundiced patients presenting to a tertiary hospital in Ghana. PLoS ONE 13(9): e0203699. https://doi.org/10.1371/ journal.pone.0203699
Abstract: Background Viral hepatitis continues to play significant role in causing morbidity and mortality in sub- Saharan Africa. Apart from the few population based studies available, not many have investigated the burden of these viruses in jaundiced patients. Among the few studies, hepatitis E is the least studied among jaundiced patients. This study was aimed at describing the frequency, distribution and risk of the different hepatitis viruses among jaundiced patients reporting to the second largest teaching hospital in Ghana. Methods From November, 2015 to April, 2016, a cross-sectional study was conducted among jaundiced patients attending the Komfo Anokye Teaching Hospital. Between 3±5 ml of blood was collected from each patient and screened for viral hepatitis agents using both serologic and molecular-based assays. Results In the 155 patients recruited, hepatitis B was the most prevalent [54.2% (95% CI = 46.0%± 62.2%)] followed by hepatitis E [32.9% (95% CI = 25.6±40.9%)]. Most cases of hepatitis E occurred as co-infections with hepatitis B (18%), with the predominant clinical feature being hepatocellular carcinoma. Risk factor variable analysis showed middle and older aged individuals were more at risk of hepatitis B exposure whereas younger age groups (<18 years) were more at risk of hepatitis E virus infection.
Description: An article published by PLoS ONE and also available at https://doi.org/10.1371/journal.pone.0203699
URI: http://hdl.handle.net/123456789/12542
Appears in Collections:College of Science

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