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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12560

Title: Genotypic characterisation of human papillomavirus infections among persons living with HIV infection; a case–control study in Kumasi, Ghana
Authors: Yar, Denis Dekugmen
Salifu, Samson Pandam
Darko, Samuel Nkansah
Sylverken, Augustina Angelina
Gyimah, Akosua Adumea
et. al
Keywords: human papillomavirus (HPV)
Genotypes
HIV
Ghana
Issue Date: Feb-2016
Publisher: John Wiley & Sons Ltd
Citation: D. D. Yar et al. Genotypic characterization of HPV infections in HIV patients. doi:10.1111/tmi.12645
Abstract: objectives The objective of this study is to describe the burden of human papillomavirus (HPV) infection among women living with HIV and non-infected women in Ghana. methods A case–control study was conducted involving 107 women living with HIV aged between 18 and 59 years (cases) and 100 non-HIV-infected apparently healthy women (controls) who were recruited from the Kumasi South Hospital, from July to December, 2014. Cervicovaginal swabs were taken from study participants to characterise 28 high- and low-risk HPV genotypes using a multiplex real-time PCR. results The overall mean age for the participants was 40.10 9.76 years. The prevalence of highrisk (hr)-HPV genotypes was significantly higher among the cases than the controls (77.4% vs. 41.6%, P < 0.0001). Overall, HPV 58 and 54 were the most predominant high-risk (18.8%) and low-risk (15.0%) genotypes detected. The two most common hr-HPV genotype isolates were 58 (18.8%) and 35 (15.9%) with 58 being the most prevalent among age group 35–44 years compared with hr-HPV 16, 18, 35 and 45, found predominantly among 18–34 age group. conclusions Significant variations exist in HPV genotypes among HIV-infected and uninfected women.
Description: An article published by John Wiley & Sons Ltd and also available at doi:10.1111/tmi.12645
URI: http://hdl.handle.net/123456789/12560
Appears in Collections:College of Science

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