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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12576

Title: Anti-inflammatory activities of extracts from Oliva sp., Patella rustica, and Littorina littorea collected from Ghana’s coastal shorelines
Authors: Borquaye, Lawrence Sheringham
Darko, Godfred
Laryea, Michael Konney
Roberts, Victor
Boateng, Richmond
et. al
Keywords: inflammation
marine mollusks
bioactivity
carrageenan
chick edema
Issue Date: 11-Aug-2017
Publisher: Cogent Biology
Citation: Lawrence Sheringham Borquaye, Godfred Darko, Michael Konney Laryea, Victor Roberts, Richmond Boateng & Edward Ntim Gasu (2017) Anti-inflammatory activities of extracts from Oliva sp., Patella rustica, and Littorina littorea collected from Ghana’s coastal shorelines, Cogent Biology, 3:1, 1364063
Abstract:  Inflammation is one of the means the human body uses to defend itself in the event of infection, trauma, or exposure to toxic substances and it is closely associated with a number of disease symptoms. Steroidal and non-steroidal antiinflammatory agents have been the drugs of choice for managing inflammation. However, reports of unpleasant side effects have necessitated a search for new anti-inflammatory agents which have minimal side effects. Marine-derived natural products continue to make significant contributions in the pharmaceutical, nutraceutical, and cosmeceutical industries and a number of extracts and compounds from marine origin have shown promise as anti-inflammatory agents. In Ghana, extracts that have been screened for their potential anti-inflammatory effects have almost exclusively come from plants. In this work, the anti-inflammatory activities of extracts from three different marine mollusks (Oliva sp., Patella rustica, and Littorina littorea) were evaluated. Extracts were obtained by cold maceration. The carrageenan-induced paw edema model in seven-day old chicks was used to evaluate anti-inflammatory potentials. Of the extracts tested, the ethyl acetate fraction of Oliva sp. was the most potent, with an ED50 of 10.16 mg/kg. The ethanol extract of L. littorea proved to be least effective in reducing inflammation, with an ED50 value of 119.80 mg/kg. When compared, extracts from Oliva sp. seemed to possess greater anti-inflammatory potentials than either P. rustica or L. littorea counterparts. The ethyl acetate fraction of Oliva sp. was a potent and promising anti-inflammatory agent and could be explored for anti-inflammatory lead compounds.
Description: An article published by Cogent Biology and also available at doi.org/10.1080/23312025.2017.1364063
URI: http://hdl.handle.net/123456789/12576
Appears in Collections:College of Science

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