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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12715

Title: Elevated adaptive immune responses are associatedwith latent infections of wuchereria bancrofti
Authors: Arndts, Kathrin
Deininger, Susanne
Specht, Sabine
Klarmann, Ute
Kwarteng, Alexander
et. al
Issue Date: 3-Apr-2012
Publisher: PLoS Neglected Tropical Diseases
Citation: Arndts K, Deininger S, Specht S, Klarmann U, Mand S, et al. (2012) Elevated Adaptive Immune Responses Are Associated with Latent Infections ofWuchereria bancrofti. PLoS Negl Trop Dis 6(4): e1611. doi:10.1371/journal.pntd.0001611Editor:Mike Doenhoff, University of Nottingham, United Kingdom
Abstract: In order to guarantee the fulfillment of their complex lifecycle, adult filarial nematodes release millions of microfilariae (MF),which are taken up by mosquito vectors. The current strategy to eliminate lymphatic filariasis as a public health problemfocuses upon interrupting this transmission through annual mass drug administration (MDA). It remains unclear however,how many rounds of MDA are required to achieve low enough levels of MF to cease transmission. Interestingly, with thedevelopment of further diagnostic tools a relatively neglected cohort of asymptomatic (non-lymphedema) amicrofilaremic(latent) individuals has become apparent. Indeed, epidemiological studies have suggested that there are equal numbers ofpatent (MF+) and latent individuals. Since the latter represent a roadblock for transmission, we studied differences inimmune responses of infected asymptomatic male individuals (n = 159) presenting either patent (n = 92 MF+) or latent(n = 67 MF2) manifestations ofWuchereria bancrofti. These individuals were selected on the basis of MF, circulating filarialantigen in plasma and detectable worm nests. Immunological profiles of either Th1/Th17, Th2, regulatory or innateresponses were determined after stimulation of freshly isolated PBMCs with either filarial-specific extract or bystanderstimuli. In addition, levels of total and filarial-specific antibodies, both IgG subclasses and IgE, were ascertained from plasma.Results from these individuals were compared with those from 22 healthy volunteers from the same endemic area.Interestingly, we observed that in contrast to MF+patients, latent infected individuals had lower numbers of worm nestsand increased adaptive immune responses including antigen-specific IL-5. These data highlight the immunosuppressivestatus of MF+individuals, regardless of age or clinical hydrocele and reveal immunological profiles associated with latencyand immune-mediated suppression of parasite transmission.
Description: An article published by PLoS Neglected Tropical Diseases and also available at doi:10.1371/journal.pntd.0001611
URI: http://hdl.handle.net/123456789/12715
Appears in Collections:College of Science

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