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Title: Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels
Authors: Arndts, Kathrin
Specht, Sabine
Debrah, Alexander Y.
Tamarozzi, Francesca
Kwarteng, Alexander
et. al
Issue Date: 20-Feb- 201
Publisher: LoS Negl Trop Dis
Citation: Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, et al. (2014) Immunoepidemiological Profiling of Onchocerciasis Patients RevealsAssociations with Microfilaria Loads and Ivermectin Intake on Both Individual and Community Levels. PLoS Negl Trop Dis 8(2): e2679. doi:10.1371/journal.pntd.0002679
Abstract: Mass drug administration (MDA) programmes againstOnchocerca volvulususe ivermectin (IVM) which targets microfilariae(MF), the worm’s offspring. Most infected individuals are hyporesponsive and present regulated immune responses despitehigh parasite burden. Recently, with MDA programmes, the existence of amicrofilaridermic (a-MF) individuals has becomeapparent but little is known about their immune responses. Within this immunoepidemiological study, we comparedparasitology, pathology and immune profiles in infection-free volunteers and infected individuals that were MF+or a-MF.The latter stemmed from villages in either Central or Ashanti regions of Ghana which, at the time of the study, had receivedup to eight or only one round of MDA respectively. Interestingly, a-MF patients had fewer nodules and decreased IL-10responses to all tested stimuli. On the other hand, this patient group displayed contrary IL-5 profiles followingin vitrostimulation or in plasma and the dampened response in the latter correlated to reduced eosinophils and associated factorsbut elevated neutrophils. Furthermore, multivariable regression analysis with covariates MF, IVM or the region (Central vs.Ashanti) revealed that immune responses were associated with different covariates: whereasO. volvulus-specific IL-5responses were primarily associated with MF, IL-10 secretion had a negative correlation with times of individual IVM therapy(IIT). All plasma parameters (eosinophil cationic protein, IL-5, eosinophils and neutrophils) were highly associated with MF.With regards to IL-17 secretion, although no differences were observed between the groups to filarial-specific or bystanderstimuli, these responses were highly associated with the region. These data indicate that immune responses are affected byboth, IIT and the rounds of IVM MDA within the community. Consequently, it appears that a lowered infection pressure dueto IVM MDA may affect the immune profile of community members even if they have not regularly participated in theprogrammes.
Description: An article published by LoS Negl Trop Dis and also available at oi:10.1371/journal.pntd.0002679
URI: http://hdl.handle.net/123456789/12716
Appears in Collections:College of Science

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