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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12723

Title: Killing filarial nematode parasites: role oftreatment options and host immuneresponse
Authors: Kwarteng, Alexander
Ahuno, Samuel Terkper
Akoto, Freda Osei
Keywords: Ivermectin
Lymphatic filariasis
Onchocerciasis
Immune response
Issue Date: 3-Oct-2016
Publisher: BioMed Central Ltd.
Abstract: Background:There is compelling evidence that not only do anti-filarials significantly reduce larval forms, but thathost immune responses also contribute to the clearance of filarial parasites; however, the underlying mechanismshave not been fully elucidated.Main text:Filarial infections caused by Wuchereria bancrofti and Brugia species (lymphatic filariasis) andOnchocerca volvulus (onchocerciasis) affect almost 200 million individuals worldwide and pose major public healthchallenges in endemic regions. Indeed, the collective disability-adjusted life years for both infections is 3.3 million.Infections with these thread-like nematodes are chronic and, although most individuals develop a regulated state, aportion develop severe forms of pathology. Mass drug administration (MDA) programmes on endemic populationsfocus on reducing prevalence of people with microfilariae, the worm's offspring in the blood, to less than 1 %.Although this has been successful in some areas, studies show that MDA will be required for longer than initiallyconceived.Conclusion:This paper highlights the mode of action of the various antifilarial treatment strategies and role of hostimmune response.
Description: An article published by BioMed Central Ltd. and also available at DOI 10.1186/s40249-016-0183-0
URI: http://hdl.handle.net/123456789/12723
Appears in Collections:College of Science

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