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|Title: ||Immunity in filarial infections: lessons from animal models and human studies|
|Authors: ||Kwarteng, Alexander|
Ahuno, S. T.
|Issue Date: ||2017|
|Publisher: ||Scandinavian Journal of Immunology|
|Abstract: ||Our understanding of immunity to filarial infection is enigmatic and continuesto be passionately debated. The mechanisms whereby filarial nematodes are killedin vivoand how these parasites avoid these mechanisms are poorly understood.Although vaccination studies in permissive animals took off seven decades ago,the exact mechanisms driving protective immunity are extensively beinginvestigated. Currently, little is known regarding the collective functions orcounter-regulatory mechanisms of the antibody isotypes in filarial infection withrespect to protective immunity. Establishing the functional role of antibodyisotypes and cytokines in the various infection phenotypes can contributeimmensely to current knowledge in filarial immunology. This paper reviewsinsight into protective immunity in filarial infection with focus on humoral andcellular responses from animal models and human studies.|
|Description: ||An article published by Scandinavian Journal of Immunology and also available at doi: 10.1111/sji.12533|
|Appears in Collections:||College of Science|
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