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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12734

Title: Antimicrobial susceptibility profile of urinary tract pathogenic infections in Diabetic patients attending a health facility in Kumasi, Ghana
Authors: Addo, Matthew Glover
Adu-Poku, Maxwell
Keywords: Susceptibility
antimicrobial sensitivity
diabetes mellitus
drug resistance
Issue Date: 2-Jun-2020
Publisher: International Journal of Pathogen Research
Citation: Adu-PokuandAddo;IJPR,4(2):37-45,2020;Articleno.IJPR.57489.
Abstract: Aims:This study seeks to investigate the antimicrobial susceptibility profile of urinary tract pathogenic infections in diabetic patients attending a health facility in Kumasi, Ghana. Study Design:A total of 285 patients were recruited using Cochran’s formula at a prevalence of 26.4% for this study from patients attending the University Hospital from April 2018 to October 2018. Data were collected using a structured questionnaire. Methodology:Clean-catch midstream urine samples were screened for the presence of pathogenic bacteria and their antimicrobial susceptibility pattern using recommended culture methods. Results:Out of the 285 patients, 125 (43.9%) were diabetic with 90 (72%) being female and 35 (28%) male. There was no association between UTI’s and gender (P=0.5799) withdiabetic patients recording higher bacteriuria compared to non-diabetics (P< 0.001).Isolates from 113 (39.4%) of the samples were identified and these included, Escherichia coli, Pseudomonas species, Klebsiella species,Proteus speciesand Staphylococcus aureus. The most predominant was E. coli62 (54.9%) followed by S. aureus24 (21.2%), Klebsiella species14(12.4%), Pseudomonas species 12(10.6%) and Proteus species1(0.9%).E. colishowed a high antimicrobial sensitivity rates against most of the tested antibiotics, gentamycin (90.3%), amikacin (98.4%), nalidixic (34%), cefotaxime (80.6%) and nitrofurantoin (93%). Proteus spp.on the other hand, showed a100% sensitivity to all the antibiotics except tetracycline, amikacin and cefotaxime. It was observed that Escherichia coliwas mostly resistant to tetracycline (96.8%), norfloxacin (69.4%) and cefotaxime (61.4%).Conclusion:S. aureus showed a higher level of resistance to tetracycline (100%). The prevalence of this study indicated that UTI among diabetic patients was relatively comparable with other studies. Amikacin and nitrofurantoin should be recommended as antimicrobials for the treatment of UTIs whilst the use of tetracycline, norfloxacin and cefotaxime should be discouraged.
Description: An article published by International Journal of Pathogen Research and also available at DOI: 10.9734/IJPR/2020/v4i230109
URI: http://hdl.handle.net/123456789/12734
Appears in Collections:College of Science

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