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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12853

Title: Phytochemical and safety evaluation of hydroethanolic leaf extract of tecomastans(L.) juss. ex kunth
Authors: Larbie, Christopher
Nyarkoh, Christabel Owusu
Adjei, Clement Owusu
Issue Date: 8-Apr-2019
Publisher: Hindawi Publishing Corporation
Abstract: Tecoma stans(yellow bell) is a popular ornamental plant mostly found in the tropical regions. It is reported to have significantpharmacological activity and has gained attention by natives of various cultures. This study focused on the phytoconstituentsscreening, antioxidant activity, and heavy metal analysis as well as the acute and subchronic toxicity of the hydroethanolicleaf extract (TSE) using standard methods. The presence of flavonoids, alkaloids, cardiac glycosides, saponins, coumarins, andterpenoids in the raw leaf of the plant was observed while the hydroethanolic extract contained coumarins, saponins, cardiacglycosides, and flavonoids. The DPPH percentage scavenging activity of the crude extract was 64.32% while the fractions, ethylacetate (55.26%), methanol (60.72%), and hydro (36.97%.), gave varying activities. The UV-Vis and FT-IR indicated the presence ofalcohols, phenols, alkanes, alkenes, carbonyls (general), aliphatic amines, aromatics, ketones, ethers, esters, carboxylic acids, alkylhalides, saturated aliphatic acids, 1∘and 2∘amines, amides, and𝛼,𝛽-unsaturated aldehydes. The heavy metal analysis showed a highlevel of iron (Fe) and zinc (Zn) in the raw leaf. The median acute toxicity (LD50) of the extract was determined to be<5000mg/kgbody weight in mice. Subchronic use for 28 days resulted in significant weight gain, reduction in platelet levels, decrease in WBCs,and increase in blood glucose compared to the normal. TSE caused no adverse effects on vital organs. No mortality was recorded.The hydroethanolic extract ofT. stanscould therefore be considered safe in moderate doses.
Description: An article published by Hindawi and also available at https://doi.org/10.1155/2019/7417624
URI: http://hdl.handle.net/123456789/12853
Appears in Collections:College of Science

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